The Missing Diversity in Human Genetic Studies.

Sirugo, Giorgio; Williams, Scott M; Tishkoff, Sarah A

Sirugo, Giorgio; Williams, Scott M; Tishkoff, Sarah A.

Afiliación

Sirugo G; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: giorgio.sirugo@pennmedicine.upenn.edu.
Williams SM; Departments of Population and Quantitative Health Sciences, and Genetics and Genome Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address: smw154@case.edu.
Tishkoff SA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: tishkoff@pennmedicine.upenn.edu.

Cell ; 177(1): 26-31, 2019 03 21.

Article en En | MEDLINE | ID: mdl-30901543

ABSTRACT

ABSTRACT

The majority of studies of genetic association with disease have been performed in Europeans. This European bias has important implications for risk prediction of diseases across global populations. In this commentary, we justify the need to study more diverse populations using both empirical examples and theoretical reasoning.

Asunto(s)

Estudios de Asociación Genética/métodos; Grupos Raciales/genética; Sesgo de Selección; Predisposición Genética a la Enfermedad/genética; Técnicas Genéticas; Variación Genética/genética; Genética/tendencias; Genética Humana/métodos; Humanos; Polimorfismo de Nucleótido Simple/genética; Factores de Riesgo

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sesgo de Selección / Grupos Raciales / Estudios de Asociación Genética Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Cell Año: 2019 Tipo del documento: Article

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