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Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin.
Miller, Sean J; Philips, Thomas; Kim, Namho; Dastgheyb, Raha; Chen, Zhuoxun; Hsieh, Yi-Chun; Daigle, J Gavin; Datta, Malika; Chew, Jeannie; Vidensky, Svetlana; Pham, Jacqueline T; Hughes, Ethan G; Robinson, Michael B; Sattler, Rita; Tomer, Raju; Suk, Jung Soo; Bergles, Dwight E; Haughey, Norman; Pletnikov, Mikhail; Hanes, Justin; Rothstein, Jeffrey D.
Afiliación
  • Miller SJ; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Philips T; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Kim N; Cellular & Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Dastgheyb R; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Chen Z; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Hsieh YC; The Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Daigle JG; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
  • Datta M; Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Chew J; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Vidensky S; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Pham JT; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Hughes EG; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Robinson MB; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Sattler R; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Tomer R; Department of Biological Sciences, Columbia University, New York, NY, USA.
  • Suk JS; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Bergles DE; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Haughey N; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Pletnikov M; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Hanes J; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Rothstein JD; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nat Neurosci ; 22(5): 741-752, 2019 05.
Article en En | MEDLINE | ID: mdl-30936556
ABSTRACT
Despite expanding knowledge regarding the role of astroglia in regulating neuronal function, little is known about regional or functional subgroups of brain astroglia and how they may interact with neurons. We use an astroglia-specific promoter fragment in transgenic mice to identify an anatomically defined subset of adult gray matter astroglia. Using transcriptomic and histological analyses, we generate a combinatorial profile for the in vivo identification and characterization of this astroglia subpopulation. These astroglia are enriched in mouse cortical layer V; express distinct molecular markers, including Norrin and leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6), with corresponding layer-specific neuronal ligands; are found in the human cortex; and modulate neuronal activity. Astrocytic Norrin appears to regulate dendrites and spines; its loss, as occurring in Norrie disease, contributes to cortical dendritic spine loss. These studies provide evidence that human and rodent astroglia subtypes are regionally and functionally distinct, can regulate local neuronal dendrite and synaptic spine development, and contribute to disease.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Corteza Cerebral / Astrocitos / Proteínas del Ojo / Proteínas del Tejido Nervioso / Neuronas Límite: Animals / Humans / Male Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Corteza Cerebral / Astrocitos / Proteínas del Ojo / Proteínas del Tejido Nervioso / Neuronas Límite: Animals / Humans / Male Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos