Molecular regulation of myoendothelial gap junctions.
Curr Opin Pharmacol
; 45: 16-22, 2019 04.
Article
en En
| MEDLINE
| ID: mdl-30999095
ABSTRACT
Myoendothelial gap junctions are involved in the regulation of vascular tone. The major connexins described in the vascular system are Cx37, Cx40, Cx43, and Cx45 with all but Cx45 found in myoendothelial connections. Although many reports on post-translational modifications of these connexins are available, only few groups have investigated their role in controlling myoendothelial communication and signal propagation. In particular, myoendothelial gap junctions serve as essential feedback pathways between vascular smooth muscle cells and endothelial cells in the regulation of vessel responses. In conclusion, myoendothelial gap junctions coordinate and shift the overall response of vessels toward relaxation and consequently limit the constriction of vessels.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Uniones Comunicantes
/
Miocitos del Músculo Liso
/
Células Endoteliales
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Pharmacol
Asunto de la revista:
FARMACOLOGIA
Año:
2019
Tipo del documento:
Article