Improved electrocatalytic activity of Au@Fe3O4 magnetic nanoparticles for sensitive dopamine detection.
Colloids Surf B Biointerfaces
; 180: 1-8, 2019 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-31009905
ABSTRACT
Substantially, noble metals are important for the development of low-cost, sensitive, selective, superior performance, and portable electrochemical sensors. Herein, we describe gold (Au) nanoparticles (NPs) systematically decorated with magnetic Fe3O4 nanocomposites on the fabrication of sensitive dopamine sensor is described. Magnetic Au@Fe3O4 nanocomposites were prepared by reducing HAuCl4 on the surfaces of Fe3O4 nanoparticles. The surface morphology of Au@Fe3O4 nanocomposites was characterized by scanning electron microscopy (SEM), X-ray powder diffraction (XRD) and transmission electron microscopy (TEM). The electrochemical behaviour of the modified electrode was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and amperometric techniques, in which it was shown to be highly sensitive and selective towards DA. The amperometric detection of dopamine sensor, using this sensing element, exhibits a wide linear response of 0-0.8 µM with a low detection limit of 2.7 nM. In addition, the fabricated electrode showed an excellent stability and good reproducibility. The proposed analytical method was successfully applied to determine the concentration of dopamine in human urine samples and the unknown concentration of DA in human urine samples No. 1, 2 and 3 were determined as 0.056 ± 0.82 × 10-3, 0.037 ± 0.87 × 10-3 and 0.020 ± 0.94 × 10-3 µM, respectively, with recoveries ranging from 97.2% to 103.4%, suggesting that the fabricated electrode can effectively detect DA in human urine samples.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Técnicas Biosensibles
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Dopamina
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Óxido Ferrosoférrico
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Técnicas Electroquímicas
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Nanopartículas de Magnetita
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Oro
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Colloids Surf B Biointerfaces
Asunto de la revista:
QUIMICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
India