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Nitroglycerin-Citrate-Ethanol Catheter Lock Solution Is Highly Effective for In Vitro Eradication of Candida auris Biofilm.
Vargas-Cruz, Nylev; Reitzel, Ruth A; Rosenblatt, Joel; Chaftari, Anne-Marie; Wilson Dib, Rita; Hachem, Ray; Kontoyiannis, Dimitrios P; Raad, Issam I.
Afiliación
  • Vargas-Cruz N; Department of Infectious Diseases, Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Reitzel RA; Department of Infectious Diseases, Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA rreitzel@mdanderson.org.
  • Rosenblatt J; Department of Infectious Diseases, Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Chaftari AM; Department of Infectious Diseases, Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Wilson Dib R; Department of Infectious Diseases, Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Hachem R; Department of Infectious Diseases, Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Kontoyiannis DP; Department of Infectious Diseases, Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Raad II; Department of Infectious Diseases, Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Antimicrob Agents Chemother ; 63(7)2019 07.
Article en En | MEDLINE | ID: mdl-31036689
ABSTRACT
Candida auris poses emerging risks for causing severe central line-associated bloodstream infections. We tested in vitro the ability of antifungal lock solutions to rapidly eradicate C. auris biofilms. Liposomal amphotericin B, amphotericin B deoxycholate, fluconazole, voriconazole, micafungin, caspofungin, and anidulafungin failed to completely eradicate all 10 tested C. auris biofilms. Conversely, nitroglycerin-citrate-ethanol (NiCE) catheter lock solution completely eradicated all replicates for all of C. auris biofilms tested.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Candida / Nitroglicerina / Ácido Cítrico / Catéteres / Antifúngicos Idioma: En Revista: Antimicrob Agents Chemother Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Candida / Nitroglicerina / Ácido Cítrico / Catéteres / Antifúngicos Idioma: En Revista: Antimicrob Agents Chemother Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos