Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption.

Tardelli, Matteo; Bruschi, Francesca V; Claudel, Thierry; Fuchs, Claudia D; Auer, Nicole; Kunczer, Victoria; Stojakovic, Tatjana; Scharnagl, Hubert; Habib, Aida; Grabner, Gernot F; Zimmermann, Robert; Lotersztajn, Sophie; Trauner, Michael

Tardelli, Matteo; Bruschi, Francesca V; Claudel, Thierry; Fuchs, Claudia D; Auer, Nicole; Kunczer, Victoria; Stojakovic, Tatjana; Scharnagl, Hubert; Habib, Aida; Grabner, Gernot F; Zimmermann, Robert; Lotersztajn, Sophie; Trauner, Michael.

Afiliación

Tardelli M; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Bruschi FV; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Claudel T; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Fuchs CD; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Auer N; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Kunczer V; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Stojakovic T; Clinical Institute of Medical and Chemical Laboratory Diagnostics University Hospital Graz, Graz, Austria.
Scharnagl H; Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Graz, Graz, Austria.
Habib A; INSERM-UMR1149, Centre de Recherche sur l'Inflammation, Paris, France.
Grabner GF; Department of Biochemistry and Molecular Genetics American University of Beirut, Beirut, Lebanon.
Zimmermann R; Institute of Molecular Biosciences University of Graz, Graz, Austria.
Lotersztajn S; Institute of Molecular Biosciences University of Graz, Graz, Austria.
Trauner M; INSERM-UMR1149, Centre de Recherche sur l'Inflammation, Paris, France.

J Lipid Res ; 60(7): 1284-1292, 2019 07.

Article en En | MEDLINE | ID: mdl-31048404

Asunto(s)

Tejido Adiposo/metabolismo; Hígado/enzimología; Hígado/metabolismo; Monoacilglicerol Lipasas/metabolismo; Ácido 3-Hidroxibutírico/sangre; Células 3T3-L1; Adiponectina/sangre; Animales; Western Blotting; Células Cultivadas; Ácidos Grasos/sangre; Glicerol/sangre; Humanos; Inmunohistoquímica; Insulina/sangre; Absorción Intestinal/genética; Absorción Intestinal/fisiología; Metabolismo de los Lípidos/genética; Metabolismo de los Lípidos/fisiología; Lipólisis/genética; Lipólisis/fisiología; Ratones; Ratones Endogámicos C57BL; Monoacilglicerol Lipasas/deficiencia; Monoacilglicerol Lipasas/genética; Obesidad/genética; Obesidad/metabolismo; Oxidación-Reducción; Receptores Activados del Proliferador del Peroxisoma/metabolismo; Triglicéridos/sangre

Palabras clave

adipocyte; adipocytes/obesity; fatty acid/metabolism; lipolysis and fatty acid metabolism; monoacylglycerol lipase; nonalcoholic fatty liver disease; nuclear receptors/peroxisome proliferator-activated receptor; obesity

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Tejido Adiposo / Hígado / Monoacilglicerol Lipasas Límite: Animals / Humans Idioma: En Revista: J Lipid Res Año: 2019 Tipo del documento: Article País de afiliación: Austria

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