Moderation Effect of Handgrip Strength on the Associations of Obesity and Metabolic Syndrome With Fatty Liver in Adolescents.
J Clin Densitom
; 23(2): 278-285, 2020.
Article
en En
| MEDLINE
| ID: mdl-31060787
ABSTRACT
INTRODUCTION/BACKGROUND:
This study aimed to evaluate the effect of handgrip strength on the associations of body mass index and metabolic syndrome with an indicator of nonalcoholic fatty liver disease in adolescents.METHODOLOGY:
In data of 1690 adolescents aged 10-18 yr from the Korea National Health and Nutrition Examination Survey 2014-2016, alanine amino-transferase levels, age, sex, bodyweight-, sex-, and age-standardized handgrip strength, age- and sex-specific body mass index Z-scores, and metabolic syndrome severity scores were assessed. Nonalcoholic fatty liver disease was defined based on alanine amino-transferase levels (boys ≥52U/L, girls ≥44U/L) in adolescents who were overweight. Moderation analysis via the PROCESS procedure was performed.RESULTS:
The prevalence of nonalcoholic fatty liver disease was 1.5% among all adolescents and 6.7% among those who were overweight. In all adolescents and adolescents who were overweight, age- and sex-specific body mass index Z-scores and metabolic syndrome scores had positive associations with nonalcoholic fatty liver disease after adjusting for bodyweight-, sex-, and age-standardized handgrip strength. Bodyweight-, sex-, and age-standardized handgrip strength had an inverse association with nonalcoholic fatty liver disease after adjusting for metabolic syndrome scores, and this association became nonsignificant after adjusting for age- and sex-specific body mass index Z-scores. There were positive associations between age- and sex-specific body mass index Z-scores and alanine amino-transferase levels when bodyweight-, sex-, and age-standardized handgrip strength values were ≤-0.13 in overweight adolescents and ≤0.74 in all adolescents, whereas these associations were nonsignificant or negative above those cut-off values. These cut-off values of bodyweight-, sex-, and age-standardized handgrip strength for the relationship between metabolic syndrome scores and alanine amino-transferase levels were -0.15 in overweight adolescents and 0.55 in all adolescents.CONCLUSIONS:
A higher bodyweight-, sex-, and age-standardized handgrip strength may attenuate the risk of obesity and metabolic syndrome for an indicator of nonalcoholic fatty liver disease in adolescents.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fuerza de la Mano
/
Síndrome Metabólico
/
Obesidad Infantil
/
Enfermedad del Hígado Graso no Alcohólico
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Clin Densitom
Asunto de la revista:
ORTOPEDIA
Año:
2020
Tipo del documento:
Article