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Slowdown intracranial glioma progression by optical hyperthermia therapy: study on a CT-2A mouse astrocytoma model.
Casanova-Carvajal, Oscar; Urbano-Bojorge, Ana Lorena; Ramos, Milagros; Serrano-Olmedo, José Javier; Martínez-Murillo, R.
Afiliación
  • Casanova-Carvajal O; Centro de Tecnología Biomédica (CTB), Universidad Politécnica de Madrid (UPM), Campus de Montegancedo, E-28223, Pozuelo de Alarcón, Madrid, Spain. Consorcio de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain. Universidad Nacional Experimental del Táchira (UNET), San Cristóbal 5001, Táchira, Venezuela.
Nanotechnology ; 30(35): 355101, 2019 Aug 30.
Article en En | MEDLINE | ID: mdl-31082814
ABSTRACT
Metallic nanorods are promising agents for a wide range of biomedical applications. We report an optical hyperthermia method capable of inducing slowdown tumor progression of an experimental in vivo CT-2A glioblastoma tumor. The tumor model used in this research is based on the transplantation of mouse astrocytoma CT-2A cells in the striatum of mice by intracranial stereotaxic surgery. Two weeks after cell implant, the resulting tumor is treated by irradiating intratumoral injected gold nanorods, biofunctionalized with CD133 antibody (B-GNRs), using a continuous wave laser. Nanoparticles convert the absorbed light into localized heat (reaching up to 44 °C) due to the effect of surface plasmon resonance. A significant slowdown in CT-2A tumor progression is evident, by histology and magnetic resonance imaging, at one (p = 0.03) and two weeks (p = 0.008) after irradiation treatment. A notable deceleration in tumor size (15%-75%) as compared to the control untreated groups, it is observed. Thus, laser irradiation of B-GNRs is found to be effective for the treatment of CT-2A tumor progression. Similarities between the pre-clinical CT-2A tumor model and the human astrocytoma disease, in terms of anatomy, metastatic behavior and histopathology, suggest that hyperthermic treatment by laser irradiation of B-GNRs administered into high-grade human astrocytoma might constitute a promising alternative treatment to limit the progression of this deadly disease.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Astrocitoma / Neoplasias Encefálicas / Nanotubos / Terapia por Láser / Oro / Hipertermia Inducida Límite: Animals / Humans Idioma: En Revista: Nanotechnology Año: 2019 Tipo del documento: Article País de afiliación: Venezuela

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Astrocitoma / Neoplasias Encefálicas / Nanotubos / Terapia por Láser / Oro / Hipertermia Inducida Límite: Animals / Humans Idioma: En Revista: Nanotechnology Año: 2019 Tipo del documento: Article País de afiliación: Venezuela