Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders.
Mol Psychiatry
; 24(9): 1248-1257, 2019 09.
Article
en En
| MEDLINE
| ID: mdl-31089192
ABSTRACT
In 2003 Rubenstein and Merzenich hypothesized that some forms of Autism (ASD) might be caused by a reduction in signal-to-noise in key neural circuits, which could be the result of changes in excitatory-inhibitory (E-I) balance. Here, we have clarified the concept of E-I balance, and updated the original hypothesis in light of the field's increasingly sophisticated understanding of neuronal circuits. We discuss how specific developmental mechanisms, which reduce inhibition, affect cortical and hippocampal functions. After describing how mutations of some ASD genes disrupt inhibition in mice, we close by suggesting that E-I balance represents an organizing framework for understanding findings related to pathophysiology and for identifying appropriate treatments.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Trastorno del Espectro Autista
/
Red Nerviosa
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Psychiatry
Asunto de la revista:
BIOLOGIA MOLECULAR
/
PSIQUIATRIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos