The facile and visualizable identification of broad-spectrum inhibitors of MDM2/p53 using co-expressed protein complexes.

Yang, Yang; Dong, Zhiqiang; Hu, Hongze; Peng, Junhui; Sheng, Yaping; Tong, Yang; Yuan, Siming; Li, Zigang; Yang, Jiaxiang; Wells, Thomas; Qu, Yun; Farrell, Nicholas P; Liu, Yangzhong

Yang, Yang; Dong, Zhiqiang; Hu, Hongze; Peng, Junhui; Sheng, Yaping; Tong, Yang; Yuan, Siming; Li, Zigang; Yang, Jiaxiang; Wells, Thomas; Qu, Yun; Farrell, Nicholas P; Liu, Yangzhong.

Afiliación

Yang Y; CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. liuyz@ustc.edu.cn.
Dong Z; CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. liuyz@ustc.edu.cn.
Hu H; CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. liuyz@ustc.edu.cn.
Peng J; CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. liuyz@ustc.edu.cn.
Sheng Y; CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. liuyz@ustc.edu.cn.
Tong Y; CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. liuyz@ustc.edu.cn.
Yuan S; CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. liuyz@ustc.edu.cn.
Li Z; School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, 518055, China.
Yang J; Department of Chemistry, Anhui University, Hefei 230601, China.
Wells T; Department of Chemistry, Virginia Commonwealth University, 1001 West Main Street, Richmond, VA 23284-2006, USA.
Qu Y; Department of Chemistry, Virginia Commonwealth University, 1001 West Main Street, Richmond, VA 23284-2006, USA.
Farrell NP; Department of Chemistry, Virginia Commonwealth University, 1001 West Main Street, Richmond, VA 23284-2006, USA.
Liu Y; CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. liuyz@ustc.edu.cn.

Analyst ; 144(12): 3773-3781, 2019 Jun 21.

Article en En | MEDLINE | ID: mdl-31089613

Asunto(s)

Bioensayo/métodos; Proteínas Luminiscentes/metabolismo; Unión Proteica/efectos de los fármacos; Proteínas Proto-Oncogénicas c-mdm2/metabolismo; Proteína p53 Supresora de Tumor/metabolismo; Secuencia de Aminoácidos; Compuestos de Anilina/química; Cromatografía de Afinidad/métodos; Complejos de Coordinación/química; Escherichia coli/genética; Histidina/genética; Histidina/metabolismo; Humanos; Mediciones Luminiscentes/métodos; Proteínas Luminiscentes/genética; Simulación del Acoplamiento Molecular; Oligopéptidos/genética; Oligopéptidos/metabolismo; Péptidos/química; Platino (Metal)/química; Prueba de Estudio Conceptual; Proteínas Proto-Oncogénicas c-mdm2/química; Proteínas Proto-Oncogénicas c-mdm2/genética; Proteína p53 Supresora de Tumor/genética

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Unión Proteica / Bioensayo / Proteína p53 Supresora de Tumor / Proteínas Proto-Oncogénicas c-mdm2 / Proteínas Luminiscentes Tipo de estudio: Diagnostic_studies / Qualitative_research Límite: Humans Idioma: En Revista: Analyst Año: 2019 Tipo del documento: Article País de afiliación: China

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