Your browser doesn't support javascript.
loading
Transplant-associated thrombotic microangiopathy: Diagnostic challenges and management strategies.
Elemary, Mohamed; Sabry, Waleed; Seghatchian, Jerard; Goubran, Hadi.
Afiliación
  • Elemary M; Saskatoon Cancer Centre and College of Medicine, University of Saskatchewan, Saskatoon, Canada. Electronic address: Mohamed.elemary@saskcancer.ca.
  • Sabry W; Saskatoon Cancer Centre and College of Medicine, University of Saskatchewan, Saskatoon, Canada.
  • Seghatchian J; International Consultancy in Blood Components Quality/Safety Improvement, Audit/Inspection and DDR Strategies, London, UK.
  • Goubran H; Saskatoon Cancer Centre and College of Medicine, University of Saskatchewan, Saskatoon, Canada.
Transfus Apher Sci ; 58(3): 347-350, 2019 Jun.
Article en En | MEDLINE | ID: mdl-31097308
Transplant-associated thrombotic microangiopathy (TA-TMA) is one of the early endothelial complications post Hematopoietic Stem Cell Transplant (HSCT). Several mechanisms during HSCT can contribute to systemic capillary endothelial damage which can lead to TA-TMA among other complications as capillary leak syndrome or engraftment syndrome. Early diagnosis of TA-TMA contributes a challenge due to overlapping clinical manifestations and the absence of specific diagnostic criteria. Incidence is greatly variable between 1-76% according to risk factors of patients and the definition used to confirm the diagnosis. The mortality rates in patients who develop severe TA-TMA are in excess of 80%. Early treatment improves the outcome. This review outlines the diagnostic challenges and therapeutic options for TA-TMA.
Asunto(s)
Palabras clave

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trasplante de Células Madre Hematopoyéticas / Síndrome de Fuga Capilar / Microangiopatías Trombóticas Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies / Screening_studies Límite: Humans Idioma: En Revista: Transfus Apher Sci Asunto de la revista: HEMATOLOGIA Año: 2019 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trasplante de Células Madre Hematopoyéticas / Síndrome de Fuga Capilar / Microangiopatías Trombóticas Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies / Screening_studies Límite: Humans Idioma: En Revista: Transfus Apher Sci Asunto de la revista: HEMATOLOGIA Año: 2019 Tipo del documento: Article