Stromal-induced mitochondrial re-education: Impact on epithelial-to-mesenchymal transition and cancer aggressiveness.
Semin Cell Dev Biol
; 98: 71-79, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-31108187
ABSTRACT
Metabolic reprogramming as well as the flexible utilisation of fuel sources by tumour cells has been considered not only intrinsic to malignant cells but also sustained by resident and/or recruited stromal cells. The complexity of tumour-stroma cross-talk is experienced by neoplastic cells through profound changes in the own metabolic machinery. In such context, mitochondria are dynamic organelles that receive, orchestrate and exchange a multiplicity of stromal cues within the tumour cells to finely regulate key metabolic and signalling pathways, allowing malignant cells to adapt and thrive in an ever-changing environment. In this review, we focus on how tumour mitochondria are coached by stromal metabolic supply and how this re-education sustains tumour malignant traits.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Células del Estroma
/
Transición Epitelial-Mesenquimal
/
Mitocondrias
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Semin Cell Dev Biol
Asunto de la revista:
EMBRIOLOGIA
Año:
2020
Tipo del documento:
Article