Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

Torrie, Leah S; Zuccotto, Fabio; Robinson, David A; Gray, David W; Gilbert, Ian H; De Rycker, Manu

Torrie, Leah S; Zuccotto, Fabio; Robinson, David A; Gray, David W; Gilbert, Ian H; De Rycker, Manu.

Afiliación

Torrie LS; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Zuccotto F; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Robinson DA; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Gray DW; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Gilbert IH; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
De Rycker M; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

PLoS One ; 14(5): e0217828, 2019.

Article en En | MEDLINE | ID: mdl-31150492

Asunto(s)

Péptidos/antagonistas & inhibidores; Fosfotransferasas/antagonistas & inhibidores; Trypanosoma brucei brucei/efectos de los fármacos; Tripanosomiasis Africana/dietoterapia; Animales; Descubrimiento de Drogas; Ensayos Analíticos de Alto Rendimiento; Humanos; Cinetocoros/efectos de los fármacos; Cinetocoros/enzimología; Péptidos/química; Fosfotransferasas/química; Fosfotransferasas/genética; Proteínas Protozoarias/antagonistas & inhibidores; Proteínas Protozoarias/química; Proteínas Protozoarias/genética; Estaurosporina/farmacología; Trypanosoma brucei brucei/enzimología; Tripanosomiasis Africana/parasitología; Zearalenona/análogos & derivados; Zearalenona/farmacología

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Péptidos / Fosfotransferasas / Trypanosoma brucei brucei / Tripanosomiasis Africana Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido

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