Comparison of mRNA expression profiles of drug-metabolizing enzymes and transporters in fresh and cryopreserved cynomolgus monkey hepatocytes.

Koeda, Akiko; Iwao, Takahiro; Nakanishi, Anna; Mizuno, Shota; Yamashita, Misaki; Sakai, Yoko; Nakamura, Katsunori; Matsunaga, Tamihide

Koeda, Akiko; Iwao, Takahiro; Nakanishi, Anna; Mizuno, Shota; Yamashita, Misaki; Sakai, Yoko; Nakamura, Katsunori; Matsunaga, Tamihide.

Afiliación

Koeda A; Ina Research Inc., Ina, Japan; Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: a-koeda@ina-research.co.jp.
Iwao T; Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan; Educational Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: tiwao@phar.nagoya-cu.ac.jp.
Nakanishi A; Educational Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: c132540@yahoo.co.jp.
Mizuno S; Educational Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: shota9117529@gmail.com.
Yamashita M; Educational Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: misaki47kumagirl@gmail.com.
Sakai Y; Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: yoko0309@phar.nagoya-cu.ac.jp.
Nakamura K; Department of Pharmacy, Ryukyu University Hospital, Okinawa, Japan. Electronic address: nkatsu@med.u-ryukyu.ac.jp.
Matsunaga T; Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan; Educational Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: tmatsu@phar.nagoya-cu.ac.jp.

Drug Metab Pharmacokinet ; 34(4): 253-263, 2019 Aug.

Article en En | MEDLINE | ID: mdl-31174977

Asunto(s)

Alanina Transaminasa/genética; Aspartato Aminotransferasas/genética; Criopreservación; L-Lactato Deshidrogenasa/genética; ARN Mensajero/genética; gamma-Glutamiltransferasa/genética; Células 3T3; Alanina Transaminasa/metabolismo; Animales; Aspartato Aminotransferasas/metabolismo; Supervivencia Celular; Células Cultivadas; Femenino; Perfilación de la Expresión Génica; Hepatocitos/metabolismo; L-Lactato Deshidrogenasa/metabolismo; Macaca fascicularis; Masculino; Ratones; ARN Mensajero/metabolismo; Reacción en Cadena en Tiempo Real de la Polimerasa; gamma-Glutamiltransferasa/metabolismo

Palabras clave

Co-culture; Cynomolgus monkey; Drug-metabolizing enzymes; Hepatocytes; Monolayer; Spheroid; Transporters; mRNA expression profiles

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Aspartato Aminotransferasas / ARN Mensajero / Criopreservación / Alanina Transaminasa / Gamma-Glutamiltransferasa / L-Lactato Deshidrogenasa Límite: Animals Idioma: En Revista: Drug Metab Pharmacokinet Asunto de la revista: FARMACOLOGIA / METABOLISMO Año: 2019 Tipo del documento: Article

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