Neuronal Small RNAs Control Behavior Transgenerationally.
Cell
; 177(7): 1814-1826.e15, 2019 06 13.
Article
en En
| MEDLINE
| ID: mdl-31178120
ABSTRACT
It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis elegans nematodes, parental responses can transmit heritable small RNAs that regulate gene expression transgenerationally. In this study, we show that a neuronal process can impact the next generations. Neurons-specific synthesis of RDE-4-dependent small RNAs regulates germline amplified endogenous small interfering RNAs (siRNAs) and germline gene expression for multiple generations. Further, the production of small RNAs in neurons controls the chemotaxis behavior of the progeny for at least three generations via the germline Argonaute HRDE-1. Among the targets of these small RNAs, we identified the conserved gene saeg-2, which is transgenerationally downregulated in the germline. Silencing of saeg-2 following neuronal small RNA biogenesis is required for chemotaxis under stress. Thus, we propose a small-RNA-based mechanism for communication of neuronal processes transgenerationally.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Conducta Animal
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Caenorhabditis elegans
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ARN de Helminto
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ARN Pequeño no Traducido
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Neuronas
Límite:
Animals
Idioma:
En
Revista:
Cell
Año:
2019
Tipo del documento:
Article
País de afiliación:
Israel