Neuroprotective effect of CuATSM on neurotoxin-induced motor neuron loss in an ALS mouse model.
Neurobiol Dis
; 130: 104495, 2019 10.
Article
en En
| MEDLINE
| ID: mdl-31181282
ABSTRACT
CuATSM is a PET-imaging agent that has recently received attention for its success in extending the lifespan in animals in several neurodegenerative disease models. In the SOD1G93A model of ALS, CuATSM prolonged mouse longevity far longer than any previously tested therapeutic agents. The mechanism underlying this outcome has not been fully understood, but studies suggest that this copper complex contributes to maintaining copper homeostasis in mitochondria. More specifically for the SOD1 model, the molecule supplies copper back to the SOD1 protein. Additionally, CuATSM demonstrated similar protective effects in various in vivo Parkinson's disease mouse models. In the current pilot study, we utilized a neurodegenerative mouse model of motor neuron degeneration induced by the neurotoxin ß-sitosterol ß-D-glucoside. In this model, slow but distinct and progressive features of sporadic ALS occur. Treatment with CuATSM kept animal behavioural performance on par with the controls and prevented the extensive motor neuron degeneration and microglia activation seen in the untreated animals. These outcomes support a broader neuroprotective role for CuATSM beyond mutant SOD models of ALS.
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Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Fármacos Neuroprotectores
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Cobre
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Esclerosis Amiotrófica Lateral
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Neuronas Motoras
Límite:
Animals
Idioma:
En
Revista:
Neurobiol Dis
Asunto de la revista:
NEUROLOGIA
Año:
2019
Tipo del documento:
Article