Supramolecular Amphiphilic Assembly Formed by the Complexation of Calixpyridinium with Alimta.
Langmuir
; 35(27): 9020-9028, 2019 07 09.
Article
en En
| MEDLINE
| ID: mdl-31203624
ABSTRACT
In this work, the host-guest interaction between calixpyridinium and anionic anticancer drug Alimta was studied in aqueous media. Spherical supramolecular amphiphilic assembly rather than simple complex was accidentally fabricated by the complexation of calixpyridinium with Alimta. It is the third kind of anionic guest to be discovered to form the higher-order assembly by the complexation of calixpyridinium besides polyanionic guest and anionic gemini surfactant guest. The finding of this assembly approach supplies a new idea to construct various self-assembly architectures in water via the complexation of calixpyridinium with anionic drugs. The resulting calixpyridinium-drug assemblies may also have the potential to adjust the effects of drugs.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Piridinas
/
Tensoactivos
/
Pemetrexed
/
Antineoplásicos
Idioma:
En
Revista:
Langmuir
Asunto de la revista:
QUIMICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
China