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Human leukocyte antigen in Japanese patients with idiopathic inflammatory myopathy.
Furukawa, Hiroshi; Oka, Shomi; Kawasaki, Aya; Hidaka, Misaki; Shimada, Kota; Kondo, Yuya; Ihata, Atsushi; Matsushita, Takashi; Matsumoto, Takumi; Hashimoto, Atsushi; Matsumoto, Isao; Komiya, Akiko; Kobayashi, Kouji; Osada, Atsumu; Katayama, Masao; Okamoto, Akira; Setoguchi, Keigo; Kono, Hajime; Hamaguchi, Yasuhito; Matsui, Toshihiro; Fukui, Naoshi; Tamura, Hiroaki; Takehara, Kazuhiko; Nagaoka, Shouhei; Sugii, Shoji; Sumida, Takayuki; Tsuchiya, Naoyuki; Tohma, Shigeto.
Afiliación
  • Furukawa H; Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Oka S; Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.
  • Kawasaki A; Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Hidaka M; Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.
  • Shimada K; Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Kondo Y; Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Ihata A; Department of Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.
  • Matsushita T; Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Fuchu, Japan.
  • Matsumoto T; Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Hashimoto A; Department of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan.
  • Matsumoto I; Department of Rheumatology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan.
  • Komiya A; Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
  • Kobayashi K; Department of Rheumatology, Kin-ikyo Chuo Hospital, Sapporo, Japan.
  • Osada A; Department of Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.
  • Katayama M; Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Okamoto A; Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.
  • Setoguchi K; Department of Clinical Laboratory, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.
  • Kono H; Department of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan.
  • Hamaguchi Y; Department of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan.
  • Matsui T; Department of Internal Medicine, Nagoya Medical Center, National Hospital Organization, Nagoya, Japan.
  • Fukui N; Department of Rheumatology, Himeji Medical Center, National Hospital Organization, Himeji, Japan.
  • Tamura H; Department of Allergy and Immunological Diseases, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
  • Takehara K; Department of Internal Medicine, Teikyo University, Tokyo, Japan.
  • Nagaoka S; Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
  • Sugii S; Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.
  • Sumida T; Department of Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.
  • Tsuchiya N; Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.
  • Tohma S; Department of Rheumatology, Kin-ikyo Chuo Hospital, Sapporo, Japan.
Mod Rheumatol ; 30(4): 696-702, 2020 Jul.
Article en En | MEDLINE | ID: mdl-31242791
ABSTRACT

Objective:

The human leukocyte antigen (HLA) is the strongest genetic risk factor for idiopathic inflammatory myopathy (IIM), and different HLA alleles have been reported to be associated with IIM susceptibility among different ethnic groups. In this study, we have investigated HLA alleles associated with IIM in Japanese patients.

Methods:

Genotyping of HLA-DRB1 and DPB1 were performed in 252 Japanese IIM patients (166 dermatomyositis [DM] and 86 polymyositis [PM] patients) and the association was analyzed with comparison to controls (n = 1026 for DRB1 and n = 413 for DPB1).

Results:

DRB1*0803 was associated with IIM (p = 1.60 × 10-5, pc = .0005, odds ratio [OR] 2.11, 95% confidence interval [CI] 1.52-2.92) and DM (p = .0004, pc = .0128, OR 2.06, 95%CI 1.40-3.02). DPB1*0501 was also associated with IIM (p = .0001, pc = .0021, OR 1.96, 95%CI 1.38-2.77) and DM (p = .0005, pc = .0075, OR 2.05, 95%CI 1.37-3.08). DRB1*0901 (p = .0012, pc = .0368, OR 0.35, 95% CI 0.18-0.69) and DPB1*0401(p = .0004, pc = .0057, OR 0.05, 95% CI 0.00-0.85) were protectively associated with PM. Two locus analyses suggested that DRB1*0901 and DPB1*0401 were independently associated with PM.

Conclusion:

Protective associations of HLA were detected in Japanese PM patients.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Alelos / Cadenas beta de HLA-DP / Cadenas HLA-DRB1 / Miositis Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Mod Rheumatol Año: 2020 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Alelos / Cadenas beta de HLA-DP / Cadenas HLA-DRB1 / Miositis Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Mod Rheumatol Año: 2020 Tipo del documento: Article País de afiliación: Japón