<i>Streptococcus pneumoniae</i> inhibits purinergic signaling and promotes purinergic receptor P2Y<sub>2</sub> internalization in alveolar epithelial cells.

Olotu, Cynthia; Lehmensiek, Felix; Koch, Bastian; Kiefmann, Martina; Riegel, Ann-Kathrin; Hammerschmidt, Sven; Kiefmann, Rainer

Streptococcus pneumoniae inhibits purinergic signaling and promotes purinergic receptor P2Y₂ internalization in alveolar epithelial cells.

Olotu, Cynthia; Lehmensiek, Felix; Koch, Bastian; Kiefmann, Martina; Riegel, Ann-Kathrin; Hammerschmidt, Sven; Kiefmann, Rainer.

Afiliación

Olotu C; Center for Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 22051 Hamburg, Germany c.olotu@uke.de.
Lehmensiek F; Center for Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 22051 Hamburg, Germany.
Koch B; Center for Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 22051 Hamburg, Germany.
Kiefmann M; Center for Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 22051 Hamburg, Germany.
Riegel AK; Center for Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 22051 Hamburg, Germany.
Hammerschmidt S; Institute of Genetics and Functional Genomics, Department of Molecular Genetics and Infection Biology, University of Greifswald, Felix-Hausdorff-Strasse 8, 17489 Greifswald, Germany.
Kiefmann R; Center for Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 22051 Hamburg, Germany.

J Biol Chem ; 294(34): 12795-12806, 2019 08 23.

Article en En | MEDLINE | ID: mdl-31289122

Asunto(s)

Células Epiteliales Alveolares/metabolismo; Receptores Purinérgicos P2Y2/metabolismo; Streptococcus pneumoniae/metabolismo; Células A549; Adenosina Trifosfato/metabolismo; Animales; Señalización del Calcio; Células Cultivadas; Humanos; Masculino; Ratas; Ratas Sprague-Dawley; Receptores Purinérgicos P2Y2/genética

Palabras clave

ATP; Streptococcus; Streptococcus pneumoniae; alveolar epithelial cells; calcium; lung; pneumonia; purinergic receptor; receptor internalization; receptor phosphorylation; virulence

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Streptococcus pneumoniae / Células Epiteliales Alveolares / Receptores Purinérgicos P2Y2 Límite: Animals / Humans / Male Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article País de afiliación: Alemania

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