Arsenic Disulfide Combined with L-Buthionine-(S, R)-Sulfoximine Induces Synergistic Antitumor Effects in Two-Dimensional and Three-Dimensional Models of MCF-7 Breast Carcinoma Cells.

Zhao, Yuxue; Tanaka, Sachiko; Yuan, Bo; Sugiyama, Kentaro; Onda, Kenji; Kiyomi, Anna; Takagi, Norio; Sugiura, Munetoshi; Hirano, Toshihiko

Zhao, Yuxue; Tanaka, Sachiko; Yuan, Bo; Sugiyama, Kentaro; Onda, Kenji; Kiyomi, Anna; Takagi, Norio; Sugiura, Munetoshi; Hirano, Toshihiko.

Afiliación

Zhao Y; *Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
Tanaka S; §Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, P. R. China.
Yuan B; *Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
Sugiyama K; *Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
Onda K; Department of Applied Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
Kiyomi A; *Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
Takagi N; *Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
Sugiura M; Department of Drug Safety and Risk Management, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
Hirano T; Department of Applied Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.

Am J Chin Med ; 47(5): 1149-1170, 2019.

Article en En | MEDLINE | ID: mdl-31311297

Asunto(s)

Antineoplásicos/farmacología; Arsenicales/farmacología; Neoplasias de la Mama/fisiopatología; Butionina Sulfoximina/farmacología; Sulfuros/farmacología; Apoptosis/efectos de los fármacos; Neoplasias de la Mama/tratamiento farmacológico; Neoplasias de la Mama/genética; Neoplasias de la Mama/metabolismo; Técnicas de Cultivo de Célula; Puntos de Control del Ciclo Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Sinergismo Farmacológico; Femenino; Humanos; Células MCF-7; Fosfatidilinositol 3-Quinasas/genética; Fosfatidilinositol 3-Quinasas/metabolismo

Palabras clave

Arsenic Disulfide; Combination Treatment; L-Buthionine-(S, R)-Sulfoximine; MCF-7 Monolayers; MCF-7 Spheroids; Synergism

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Arsenicales / Sulfuros / Neoplasias de la Mama / Butionina Sulfoximina / Antineoplásicos Límite: Female / Humans Idioma: En Revista: Am J Chin Med Año: 2019 Tipo del documento: Article País de afiliación: Japón

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