Biogenesis of lysosome-related organelles complex-1 (BORC) regulates late endosomal/lysosomal size through PIKfyve-dependent phosphatidylinositol-3,5-bisphosphate.

Yordanov, Teodor E; Hipolito, Victoria E B; Liebscher, Gudrun; Vogel, Georg F; Stasyk, Taras; Herrmann, Caroline; Geley, Stephan; Teis, David; Botelho, Roberto J; Hess, Michael W; Huber, Lukas A

Yordanov, Teodor E; Hipolito, Victoria E B; Liebscher, Gudrun; Vogel, Georg F; Stasyk, Taras; Herrmann, Caroline; Geley, Stephan; Teis, David; Botelho, Roberto J; Hess, Michael W; Huber, Lukas A.

Afiliación

Yordanov TE; Division of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Hipolito VEB; Department of Chemistry and Biology and the Graduate Program in Molecular Science, Ryerson University, Toronto, Ontario, Canada.
Liebscher G; Division of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Vogel GF; Division of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Stasyk T; Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria.
Herrmann C; Division of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Geley S; Division of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Teis D; Division of Molecular Pathophysiology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Botelho RJ; Division of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Hess MW; Department of Chemistry and Biology and the Graduate Program in Molecular Science, Ryerson University, Toronto, Ontario, Canada.
Huber LA; Division of Histology and Embryology, Medical University of Innsbruck, Innsbruck, Austria.

Traffic ; 20(9): 674-696, 2019 09.

Article en En | MEDLINE | ID: mdl-31314175

Asunto(s)

Endosomas/metabolismo; Proteínas de Membrana de los Lisosomas/metabolismo; Lisosomas/metabolismo; Fosfatos de Fosfatidilinositol/metabolismo; Quinasas de la Proteína-Quinasa Activada por el AMP; Animales; Autofagia; Células HEK293; Células HeLa; Humanos; Proteína 1 de la Membrana Asociada a los Lisosomas/metabolismo; Proteínas de Membrana de los Lisosomas/genética; Sistema de Señalización de MAP Quinasas; Ratones; Fosfatidilinositol 3-Quinasas/genética; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Quinasas/metabolismo; Proteínas/genética; Proteínas/metabolismo

Palabras clave

AMP-activated protein kinase (AMPK); BORC; LAMTOR; PIKfyve; late endosome; lysosomal reformation; organelle size; phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2]

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Endosomas / Fosfatos de Fosfatidilinositol / Proteínas de Membrana de los Lisosomas / Lisosomas Límite: Animals / Humans Idioma: En Revista: Traffic Asunto de la revista: FISIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Austria

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