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[Study on liver protection and hepatotoxicity of saikosaponin a based on zebrafish model].
Xia, Qing; Han, Li-Wen; Zhang, Yun; He, Qiu-Xia; Zhang, Shan-Shan; Gao, Jing-Jing; Liu, Ke-Chun; Tu, Peng-Fei.
Afiliación
  • Xia Q; Biology Institute,Qilu University of Technology (Shandong Academy of Sciences) Ji'nan 250103,China.
  • Han LW; Biology Institute,Qilu University of Technology (Shandong Academy of Sciences) Ji'nan 250103,China.
  • Zhang Y; Biology Institute,Qilu University of Technology (Shandong Academy of Sciences) Ji'nan 250103,China.
  • He QX; Biology Institute,Qilu University of Technology (Shandong Academy of Sciences) Ji'nan 250103,China.
  • Zhang SS; Biology Institute,Qilu University of Technology (Shandong Academy of Sciences) Ji'nan 250103,China.
  • Gao JJ; Biology Institute,Qilu University of Technology (Shandong Academy of Sciences) Ji'nan 250103,China.
  • Liu KC; Biology Institute,Qilu University of Technology (Shandong Academy of Sciences) Ji'nan 250103,China.
  • Tu PF; State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University Beijing 100191,China.
Zhongguo Zhong Yao Za Zhi ; 44(13): 2662-2666, 2019 Jul.
Article en Zh | MEDLINE | ID: mdl-31359674
ABSTRACT
Bupleuri Radix has both liver protection and hepatotoxicity. Saponins are the main pharmacodynamic and toxic components of Bupleuri Radix. Based on zebrafish physical model and the model of alcoholic fatty liver( AFL) pathology,the liver toxic and protective effect of saikosaponin a( SSa) were assessed. The results indicated that 1. 77 µmol·L-1 SSa showed protective effect to AFL zebrafish. 5. 30 µmol·L-1 SSa was hepatotoxic to healthy zebrafish,but it showed protective effect to AFL zebrafish. 5. 62 µmol·L-1 SSa was hepatotoxic to healthy and AFL zebrafish. This study is benefit for clinical safety of saikosaponin a.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ácido Oleanólico / Saponinas / Hígado Graso Alcohólico / Enfermedad Hepática Inducida por Sustancias y Drogas Límite: Animals Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Asunto de la revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Año: 2019 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ácido Oleanólico / Saponinas / Hígado Graso Alcohólico / Enfermedad Hepática Inducida por Sustancias y Drogas Límite: Animals Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Asunto de la revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Año: 2019 Tipo del documento: Article País de afiliación: China