The interaction of maternal diabetes with mutations that affect folate metabolism and how they affect the development of neural tube defects in mice.
Dev Dyn
; 248(10): 900-917, 2019 10.
Article
en En
| MEDLINE
| ID: mdl-31361376
ABSTRACT
BACKGROUND:
Abnormalities in maternal folate and carbohydrate metabolism have both been shown to induce neural tube defects (NTDs) in humans and animal models. Nevertheless, how these two factors might interact in the development of NTDs remains unclear.RESULTS:
In specific mouse models and embryo culture systems, we assessed the effects of combining maternal diabetes with mutations in genes involved in folate transport and metabolism (methylenetetrahydrofolate reductase [Mthfr] and folic acid receptor 1 [Folr1]). When maternal hyperglycemia is combined with alterations in folic acid metabolism, there appears to be an increase in the incidence of congenital malformations in the offspring, with NTDs representing the majority of the malformations detected.CONCLUSIONS:
The teratogenic effects of diabetes during pregnancy are exacerbated when combined with altered embryonic folate metabolism.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Diabetes Mellitus
/
Ácido Fólico
/
Mutación
/
Defectos del Tubo Neural
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Dev Dyn
Asunto de la revista:
ANATOMIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
España