&#945;-Arbutin Protects Against Parkinson's Disease-Associated Mitochondrial Dysfunction In Vitro and In Vivo.

Ding, Yaqi; Kong, Deqin; Zhou, Tong; Yang, Nai-di; Xin, Chenqi; Xu, Jiajia; Wang, Qi; Zhang, Hang; Wu, Qiong; Lu, Xiaomei; Lim, Kahleong; Ma, Bo; Zhang, Chengwu; Li, Lin; Huang, Wei

α-Arbutin Protects Against Parkinson's Disease-Associated Mitochondrial Dysfunction In Vitro and In Vivo.

Ding, Yaqi; Kong, Deqin; Zhou, Tong; Yang, Nai-di; Xin, Chenqi; Xu, Jiajia; Wang, Qi; Zhang, Hang; Wu, Qiong; Lu, Xiaomei; Lim, Kahleong; Ma, Bo; Zhang, Chengwu; Li, Lin; Huang, Wei.

Afiliación

Ding Y; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, People's Republic of China.
Kong D; Department of Toxicology, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Shaanxi Provincial Key Lab of Free Radical Biology and Medicine, School of Public Health, The Medical University of Air Force, Xi'an, 710032, People's Republic of China.
Zhou T; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, People's Republic of China.
Yang ND; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, People's Republic of China.
Xin C; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, People's Republic of China.
Xu J; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, People's Republic of China.
Wang Q; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, People's Republic of China.
Zhang H; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, People's Republic of China.
Wu Q; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, People's Republic of China.
Lu X; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, People's Republic of China.
Lim K; Department of Physiology, School of Medicine, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077, Singapore.
Ma B; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.
Zhang C; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, People's Republic of China. iamcwzhang@njtech.edu.cn.
Li L; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, People's Republic of China. iamlli@njtech.edu.cn.
Huang W; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, People's Republic of China.

Neuromolecular Med ; 22(1): 56-67, 2020 03.

Article en En | MEDLINE | ID: mdl-31401719

Asunto(s)

Antioxidantes/uso terapéutico; Arbutina/uso terapéutico; Ericaceae/química; Mitocondrias/efectos de los fármacos; Fármacos Neuroprotectores/uso terapéutico; Enfermedad de Parkinson/tratamiento farmacológico; Fitoterapia; Extractos Vegetales/química; Adenosina Trifosfato/biosíntesis; Adenilato Quinasa/metabolismo; Animales; Antioxidantes/aislamiento & purificación; Antioxidantes/farmacología; Apoptosis/efectos de los fármacos; Arbutina/aislamiento & purificación; Arbutina/farmacología; Autofagia/efectos de los fármacos; Línea Celular Tumoral; Proteínas de Drosophila/deficiencia; Proteínas de Drosophila/genética; Drosophila melanogaster/efectos de los fármacos; Drosophila melanogaster/genética; Evaluación Preclínica de Medicamentos; Femenino; Humanos; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Mitocondrias/fisiología; Neuroblastoma/patología; Fármacos Neuroprotectores/aislamiento & purificación; Fármacos Neuroprotectores/farmacología; Oxidación-Reducción; Estrés Oxidativo/efectos de los fármacos; Enfermedad de Parkinson/metabolismo; Trastornos Parkinsonianos/tratamiento farmacológico; Rotenona/toxicidad; Ubiquitina-Proteína Ligasas/deficiencia; Ubiquitina-Proteína Ligasas/genética

Palabras clave

Autophagy; Mitochondria; Oxidative stress; Parkinson's disease; α-Arbutin

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Arbutina / Extractos Vegetales / Fármacos Neuroprotectores / Ericaceae / Fitoterapia / Mitocondrias / Antioxidantes Tipo de estudio: Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: Neuromolecular Med Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2020 Tipo del documento: Article

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