Radiation unlocks the therapeutic potential of immune checkpoint blockers in lung cancer patients.
Oncoimmunology
; 8(8): 1606624, 2019.
Article
en En
| MEDLINE
| ID: mdl-31413913
ABSTRACT
CTLA4 blockers have limited activity in patients with chemorefractory lung cancer. Recent clinical data demonstrate that radiation therapy combined with CTLA4 blockers enables disease control in a sizeable fraction of these patients, correlating with increased circulating levels of type I interferon and dynamic changes in the peripheral T cell repertoire.
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Bases de datos:
MEDLINE
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En
Revista:
Oncoimmunology
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos