Induction of poly(ADP-ribose) polymerase gene expression in lectin-stimulated human T lymphocytes is dependent on protein synthesis.
Biochem Biophys Res Commun
; 156(2): 995-9, 1988 Oct 31.
Article
en En
| MEDLINE
| ID: mdl-3142469
ABSTRACT
The poly(ADP-ribose) polymerase mRNA level in quiescent T lymphocytes was low, but was significantly higher than that in B lymphocytes or monocytes. When T lymphocytes were stimulated with phytohemagglutinin, a prompt increase in the mRNA level was observed from 4 hours after stimulation. The level of poly(ADP-ribose) polymerase mRNA reached a maximum in the late G1 phase about 1-2 days after lectin stimulation, and then decreased gradually returning to the basal level 10 days after lectin stimulation. Cycloheximide abrogated increase in poly(ADP-ribose) polymerase gene expression suggesting that a newly synthesized protein(s) was involved in poly(ADP-ribose) polymerase gene induction in lectin-stimulated T lymphocytes.
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Bases de datos:
MEDLINE
Asunto principal:
Fitohemaglutininas
/
Biosíntesis de Proteínas
/
Linfocitos T
/
Regulación de la Expresión Génica
/
Poli(ADP-Ribosa) Polimerasas
Límite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
1988
Tipo del documento:
Article
País de afiliación:
Italia