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DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers.
Grievink, Hendrika W; Heuberger, Jules A A C; Huang, Fen; Chaudhary, Rinkal; Birkhoff, Willem A J; Tonn, George R; Mosesova, Sofia; Erickson, Rebecca; Moerland, Matthijs; Haddick, Patrick C G; Scearce-Levie, Kimberly; Ho, Carole; Groeneveld, Geert Jan.
Afiliación
  • Grievink HW; Centre for Human Drug Research, Leiden, The Netherlands.
  • Heuberger JAAC; Centre for Human Drug Research, Leiden, The Netherlands.
  • Huang F; Denali Therapeutics, South San Francisco, California, USA.
  • Chaudhary R; Denali Therapeutics, South San Francisco, California, USA.
  • Birkhoff WAJ; Centre for Human Drug Research, Leiden, The Netherlands.
  • Tonn GR; Denali Therapeutics, South San Francisco, California, USA.
  • Mosesova S; Denali Therapeutics, South San Francisco, California, USA.
  • Erickson R; Denali Therapeutics, South San Francisco, California, USA.
  • Moerland M; Centre for Human Drug Research, Leiden, The Netherlands.
  • Haddick PCG; Denali Therapeutics, South San Francisco, California, USA.
  • Scearce-Levie K; Denali Therapeutics, South San Francisco, California, USA.
  • Ho C; Denali Therapeutics, South San Francisco, California, USA.
  • Groeneveld GJ; Centre for Human Drug Research, Leiden, The Netherlands.
Clin Pharmacol Ther ; 107(2): 406-414, 2020 02.
Article en En | MEDLINE | ID: mdl-31437302
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteína Serina-Treonina Quinasas de Interacción con Receptores Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Pharmacol Ther Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
Imprimir
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PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteína Serina-Treonina Quinasas de Interacción con Receptores Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Pharmacol Ther Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos