Mechanical strain induces a pro-fibrotic phenotype in human mitral valvular interstitial cells through RhoC/ROCK/MRTF-A and Erk1/2 signaling pathways.

Blomme, Benoit; Deroanne, Christophe; Hulin, Alexia; Lambert, Charles; Defraigne, Jean-Olivier; Nusgens, Betty; Radermecker, Marc; Colige, Alain

Blomme, Benoit; Deroanne, Christophe; Hulin, Alexia; Lambert, Charles; Defraigne, Jean-Olivier; Nusgens, Betty; Radermecker, Marc; Colige, Alain.

Afiliación

Blomme B; Laboratory of Connective Tissues Biology, GIGA-Research, University of Liège, Tour de Pathologie, B23, 4000 Sart-Tilman, Belgium; Department of Cardiovascular and Thoracic Surgery, B35, University of Liège, CHU Sart-Tilman, 4000 Sart Tilman, Belgium.
Deroanne C; Laboratory of Connective Tissues Biology, GIGA-Research, University of Liège, Tour de Pathologie, B23, 4000 Sart-Tilman, Belgium.
Hulin A; Laboratory of Cardiology, GIGA-Cardiovascular Sciences, B34, University of Liège, 4000 Sart- Tilman, Belgium.
Lambert C; Laboratory of Connective Tissues Biology, GIGA-Research, University of Liège, Tour de Pathologie, B23, 4000 Sart-Tilman, Belgium.
Defraigne JO; Department of Cardiovascular and Thoracic Surgery, B35, University of Liège, CHU Sart-Tilman, 4000 Sart Tilman, Belgium.
Nusgens B; Laboratory of Connective Tissues Biology, GIGA-Research, University of Liège, Tour de Pathologie, B23, 4000 Sart-Tilman, Belgium.
Radermecker M; Department of Cardiovascular and Thoracic Surgery, B35, University of Liège, CHU Sart-Tilman, 4000 Sart Tilman, Belgium; Department of Human Anatomy, B23, University of Liège, CHU Sart-Tilman, 4000 Sart Tilman, Belgium.
Colige A; Laboratory of Connective Tissues Biology, GIGA-Research, University of Liège, Tour de Pathologie, B23, 4000 Sart-Tilman, Belgium. Electronic address: acolige@uliege.be.

J Mol Cell Cardiol ; 135: 149-159, 2019 10.

Article en En | MEDLINE | ID: mdl-31442470

Asunto(s)

Estenosis de la Válvula Aórtica/genética; Calcinosis/genética; Fibrosis/genética; Válvula Mitral/metabolismo; Válvula Aórtica/metabolismo; Válvula Aórtica/patología; Estenosis de la Válvula Aórtica/patología; Calcinosis/patología; Fibrosis/patología; Humanos; Sistema de Señalización de MAP Quinasas/genética; Válvula Mitral/patología; Estrés Mecánico; Transactivadores/genética; Quinasas Asociadas a rho/genética; Proteína de Unión al GTP rhoA/genética

Palabras clave

CTGF/CCN2; Heart valve disease; MMV; MRTF-A; Mechanical strain; RhoGTPases

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Estenosis de la Válvula Aórtica / Fibrosis / Calcinosis / Válvula Mitral Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Mol Cell Cardiol Año: 2019 Tipo del documento: Article País de afiliación: Bélgica

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