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Self-reported Neurocognitive Impairment in People Living With Human Immunodeficiency Virus (HIV): Characterizing Clusters of Patients With Similar Changes in Self-reported Neurocognitive Impairment, 2013-2017, in the Swiss HIV Cohort Study.
Kusejko, Katharina; Salazar-Vizcaya, Luisa; Braun, Dominique L; Tarr, Philip E; Bernasconi, Enos; Doco-Lecompte, Thanh; Cavassini, Matthias; Schmid, Patrick; Du Pasquier, Renaud; Hauser, Christoph; Günthard, Huldrych F; Kouyos, Roger D.
Afiliación
  • Kusejko K; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
  • Salazar-Vizcaya L; Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
  • Braun DL; Clinic for Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Tarr PE; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
  • Bernasconi E; Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
  • Doco-Lecompte T; University Department of Medicine, Kantonsspital Baselland, University of Basel, Basel, Switzerland.
  • Cavassini M; Division of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland.
  • Schmid P; Department of Infectious Diseases, HIV Unit, Geneva University Hospital, University of Geneva, Geneva, Switzerland.
  • Du Pasquier R; Division of Infectious Diseases, Lausanne University Hospital, Lausanne, Switzerland.
  • Hauser C; Division of Infectious Diseases, Cantonal Hospital St Gallen, St. Gallen, Switzerland.
  • Günthard HF; Department of Clinical Neurosciences, Service of Neurology, Neuroimmunology Unit, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
  • Kouyos RD; Clinic for Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
Clin Infect Dis ; 71(3): 637-644, 2020 07 27.
Article en En | MEDLINE | ID: mdl-31504323
BACKGROUND: Self-reported neurocognitive impairment (SRNI) in people living with human immunodeficiency virus type 1 (HIV-1) infection is frequent. We use longitudinal information on SRNI in the Swiss HIV Cohort Study (SHCS) to identify and characterize groups of patients with persisting SRNI over time. METHODS: We included all SHCS patients who were assessed for SRNI during at least 5 visits spanning at least 2.5 years in 2013-2017. We first compared patients with SRNI to those without SRNI over the whole study period. Second, we used a hierarchical cluster algorithm to identify groups of patients with similar changes of SRNI over time. In both analyses, we studied clinical and demographic factors potentially influencing SRNI. RESULTS: In total, 79 683 questionnaires of 11 029 patients contained information about SRNI, and 8545 of 11 029 (77.5%) patients had longitudinal information. The overall percentage of patients with SRNI decreased from 19.6% in 2013 to 10.7% in 2017. Compared to patients in the cluster with low-level SRNI over time, patients in the cluster with high-level persisting SRNI more often had a prior opportunistic infection of the central nervous system (CNS) (odds ratio [OR], 3.7; P < .001), imperfect adherence to antiretroviral therapy (ART) (OR, 2.8; P < .001), and depression (OR, 1.9; P < .001). CONCLUSIONS: Although overall SRNI is decreasing in the SHCS, there is a group of patients with persisting SRNI over time. Past opportunistic infections of the CNS, imperfect adherence to ART, and depression were associated most with persisting SRNI. Patients with these characteristics should be preferentially tested for neurocognitive impairment.Although overall self-reported neurocognitive impairment (SRNI) is decreasing in the Swiss HIV Cohort Study, there is a group of patients with persisting SRNI over time, characterized by more past opportunistic infections of the central nervous system, imperfect adherence to antiretroviral therapy, and depression.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2020 Tipo del documento: Article País de afiliación: Suiza

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2020 Tipo del documento: Article País de afiliación: Suiza