Distribution analysis of single nucleotide polymorphisms related to feet and legs and their association with lameness in Vrindavani cattle.
Trop Anim Health Prod
; 52(2): 851-858, 2020 Mar.
Article
en En
| MEDLINE
| ID: mdl-31520341
ABSTRACT
Lameness is one of the most serious economic problems in dairy animals. The present study was undertaken to identify the SNPs associated with lameness in Vrindavani, a synthetic crossbred cattle developed in India. A total of 187 cows were screened for lameness at Cattle and Buffalo Farm, Indian Veterinary Research Institute, Izatnagar, India and 16.04% prevalence was noticed. The effect of age, body weight, parity, and peak yield was not significant on lameness score. Heritability estimate of lameness score was low (0.07 ± 0.01). A total of 90 Vrindavani cows were genotyped by PCR-RFLP for 10 SNPs that were reported to have association with feet and legs in cattle. Five SNPs displayed significant departure from Hardy Weinberg equilibrium. Varying levels of heterozygosity, polymorphic information content, and allelic diversity were noticed at different SNPs. Odds ratio and least squares analysis revealed a significant association (P < 0.05) of three SNPs with lameness in the herd. Cows with AG, TT, and GG genotypes respectively at rs41632254, rs41603160, and rs41636945 loci were less prone to lameness. These genetic markers would certainly aid in development of an early detection system for lameness.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Polimorfismo de Longitud del Fragmento de Restricción
/
Enfermedades de los Bovinos
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Polimorfismo de Nucleótido Simple
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Cojera Animal
Tipo de estudio:
Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
Trop Anim Health Prod
Año:
2020
Tipo del documento:
Article
País de afiliación:
India