CUDC-101 overcomes arsenic trioxide resistance via caspase-dependent promyelocytic leukemia-retinoic acid receptor alpha degradation in acute promyelocytic leukemia.

Zhang, Tianzhuo; Ma, Dan; Wei, Danna; Lu, Tingting; Yu, Kunlin; Zhang, Zhaoyuan; Wang, Weili; Fang, Qin; Wang, Jishi

Zhang, Tianzhuo; Ma, Dan; Wei, Danna; Lu, Tingting; Yu, Kunlin; Zhang, Zhaoyuan; Wang, Weili; Fang, Qin; Wang, Jishi.

Afiliación

Zhang T; Department of Clinical Medical School, Guizhou Medical University.
Ma D; Department of Hematology, Affiliated Hospital of Guizhou Medical University.
Wei D; Department of Guizhou Province Hematopoietic Stem Cell Transplantation Center and Key Laboratory of Hematological Disease Diagnostic and Treatment Centre.
Lu T; Department of Clinical Medical School, Guizhou Medical University.
Yu K; Department of Hematology, Affiliated Hospital of Guizhou Medical University.
Zhang Z; Department of Hematology and Oncology, Guiyang Maternal and Child Health Hospital.
Wang W; Department of Clinical Medical School, Guizhou Medical University.
Fang Q; Department of Hematology, Affiliated Hospital of Guizhou Medical University.
Wang J; Department of Clinical Medical School, Guizhou Medical University.

Anticancer Drugs ; 31(2): 158-168, 2020 02.

Article en En | MEDLINE | ID: mdl-31584454

Asunto(s)

Trióxido de Arsénico/farmacología; Caspasas/metabolismo; Resistencia a Antineoplásicos/efectos de los fármacos; Regulación Neoplásica de la Expresión Génica; Ácidos Hidroxámicos/farmacología; Leucemia Promielocítica Aguda/tratamiento farmacológico; Quinazolinas/farmacología; Receptor alfa de Ácido Retinoico/metabolismo; Animales; Antineoplásicos/farmacología; Apoptosis; Biomarcadores de Tumor; Proliferación Celular; Femenino; Humanos; Leucemia Promielocítica Aguda/metabolismo; Leucemia Promielocítica Aguda/patología; Ratones; Ratones Endogámicos NOD; Ratones SCID; Pronóstico; Células Tumorales Cultivadas; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Quinazolinas / Leucemia Promielocítica Aguda / Regulación Neoplásica de la Expresión Génica / Resistencia a Antineoplásicos / Caspasas / Receptor alfa de Ácido Retinoico / Trióxido de Arsénico / Ácidos Hidroxámicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Anticancer Drugs Asunto de la revista: ANTINEOPLASICOS Año: 2020 Tipo del documento: Article

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