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Gene network analysis reveals a role for striatal glutamatergic receptors in dysregulated risk-assessment behavior of autism mouse models.
Oron, Oded; Getselter, Dmitriy; Shohat, Shahar; Reuveni, Eli; Lukic, Iva; Shifman, Sagiv; Elliott, Evan.
Afiliación
  • Oron O; Molecular and Behavioral Neurosciences Lab, Bar-Ilan University Faculty of Medicine, 1311502, Safed, Israel.
  • Getselter D; Molecular and Behavioral Neurosciences Lab, Bar-Ilan University Faculty of Medicine, 1311502, Safed, Israel.
  • Shohat S; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, 9190501, Jerusalem, Israel.
  • Reuveni E; Molecular and Behavioral Neurosciences Lab, Bar-Ilan University Faculty of Medicine, 1311502, Safed, Israel.
  • Lukic I; Molecular and Behavioral Neurosciences Lab, Bar-Ilan University Faculty of Medicine, 1311502, Safed, Israel.
  • Shifman S; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, 9190501, Jerusalem, Israel.
  • Elliott E; Molecular and Behavioral Neurosciences Lab, Bar-Ilan University Faculty of Medicine, 1311502, Safed, Israel. evan.elliott@biu.ac.il.
Transl Psychiatry ; 9(1): 257, 2019 10 17.
Article en En | MEDLINE | ID: mdl-31624228
Autism spectrum disorder (ASD) presents a wide, and often varied, behavioral phenotype. Improper assessment of risks has been reported among individuals diagnosed with ASD. Improper assessment of risks may lead to increased accidents and self-injury, also reported among individuals diagnosed with ASD. However, there is little knowledge of the molecular underpinnings of the impaired risk-assessment phenotype. In this study, we have identified impaired risk-assessment activity in multiple male ASD mouse models. By performing network-based analysis of striatal whole transcriptome data from each of these ASD models, we have identified a cluster of glutamate receptor-associated genes that correlate with the risk-assessment phenotype. Furthermore, pharmacological inhibition of striatal glutamatergic receptors was able to mimic the dysregulation in risk-assessment. Therefore, this study has identified a molecular mechanism that may underlie risk-assessment dysregulation in ASD.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores de Glutamato / Cuerpo Estriado / Trastorno del Espectro Autista Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Transl Psychiatry Año: 2019 Tipo del documento: Article País de afiliación: Israel

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores de Glutamato / Cuerpo Estriado / Trastorno del Espectro Autista Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Transl Psychiatry Año: 2019 Tipo del documento: Article País de afiliación: Israel