Current and Emerging Therapies for Mitochondriopathies.
Handb Exp Pharmacol
; 261: 57-65, 2020.
Article
en En
| MEDLINE
| ID: mdl-31628601
ABSTRACT
Mitochondrial diseases are a clinically and genetically heterogeneous group of disorders. The underlying dysfunction of the mitochondrial electron transport chain and oxidative phosphorylation is caused by variants of genes encoding mitochondrial proteins. Despite substantial advances in the understanding of the mechanism of these diseases, there are still no satisfactory therapies available. Therapeutic strategies include the use of antioxidants, inducers of mitochondrial biogenesis, enhancers of electron transfer chain function, energy buffers, amino acids restoring NO production, nucleotide bypass therapy, liver transplantation, and gene therapy. Although there are some promising projects underway, to date satisfactory therapies are missing.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedades Mitocondriales
Límite:
Humans
Idioma:
En
Revista:
Handb Exp Pharmacol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Austria