A small cytotoxic peptide from frog elicits potent antitumor immunity to prevent local tumor growth and metastases.
Future Med Chem
; 11(19): 2505-2525, 2019 10.
Article
en En
| MEDLINE
| ID: mdl-31633400
ABSTRACT
Aim:
Anticancer immunochemotherapy represents an attractive paradigm to improve therapeutic responses and reduce side effects. Results &methodology:
Here, we show that a naturally occurring host defense peptide, HN-1 inhibited multiple malignant cells proliferation and tumor growth in a xenografted human breast tumor model. Acting through MAPK/NF-κB pathways, HN-1 induced a caspase-independent mitochondrial apoptosis, as indicated by a p53-dependent increase of Bax/Bcl-2 ratio and the nuclear translocation of apoptosis inducing factor. Besides, HN-1 augmented CD4+/CD8+ T cells in 4T1 mammary carcinoma model, by enhancing the serum levels of cancer immunity-associated effectors. Meanwhile, HN-1 decreased the angiogenesis and infiltration of the tumor-associated macrophages.Conclusion:
HN-1 induces caspase-independent cancer cells apoptosis and boosts cancer-resolving immunity without inducing potentially harmful pro-inflammatory responses.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Oligopéptidos
/
Antineoplásicos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Future Med Chem
Año:
2019
Tipo del documento:
Article
País de afiliación:
China