Transcytosis of Nanomedicine for Tumor Penetration.
Nano Lett
; 19(11): 8010-8020, 2019 11 13.
Article
en En
| MEDLINE
| ID: mdl-31639306
ABSTRACT
The diffusion of nanomedicines used to treat tumors is severely hindered by the microenvironment, which is a challenge that has emerged as a bottleneck for the effective outcome of nanotherapies. Classical strategies for enhancing tumor penetration rely on passive movement in the extracellular matrix (ECM). Here, we demonstrate that nanomedicine also penetrates tumor lesions via an active trans-cell transportation process. This process was discovered by directly observing the movement of nanoparticles between cells, evaluating the intracellular trafficking pathway of nanoparticles via Rab protein labeling, comparing endocytosis-exocytosis between nanoparticles administered with inhibitors, and correlating the transcytosis process with the micro-CT distribution of nanomedicines. We also demonstrated that enhanced tumor penetration promotes the therapeutic efficacy of a photodynamic therapeutic nanomedicine. Our research thus suggests that transcytosis could be an important positive factor for designing cancer nanomedicines.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fármacos Fotosensibilizantes
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Nanopartículas
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Transcitosis
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Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Nano Lett
Año:
2019
Tipo del documento:
Article