What are the economic burden and costs associated with the treatment of breast cancer-related lymphoedema? A systematic review.
Support Care Cancer
; 28(2): 439-449, 2020 Feb.
Article
en En
| MEDLINE
| ID: mdl-31656987
ABSTRACT
OBJECTIVES:
To provide an overview of costs associated with the treatment of breast cancer-related lymphoedema (BCRL) and its possible sequelae, borne by patients or by society. DATA SOURCES According to the PRISMA guideline, a systematic literature search was carried out in four electronic databases PubMed, Web of Science, Cochrane Clinical Trials and EMBASE. Searches were performed on October 1, 2018. STUDY SELECTION Eligibility criteria (1) expenses of adults (age > 18 years), (2) concerning patients with BCRL, (3) overview of (in)direct costs associated with BCRL, (4) expenses in which at least one type of conservative treatment modality for lymphoedema is included and/or costs for hospital admissions due to infections. Reviews and meta-analyses were excluded. DATA EXTRACTION After assessing the risk of bias and level of evidence, quantitative data on (in)direct costs for BCRL treatment during a well-mentioned timeframe were extracted. DATASYNTHESIS:
Eight studies were included. Three studies reported on patient-borne costs related to BCRL. Mean direct costs per year borne by patients ranged between USD$2306 and USD$2574. Indirect costs borne by patients ranged between USD$3325 and USD$5545 per year. Five studies estimated society-borne costs related to BCRL from claims data, billing prices and providers' services during 12 to 24 months of follow-up. Mean direct treatment costs after 1 year of decongestive lymphatic therapy (DLT) ranged between 799 (= USD$1126.60) and USD$3165.CONCLUSION:
This systematic review revealed that BCRL imposes a substantial economic burden on patients and society. However, more standardized high-quality health economic analyses among this field are required. Recent economic analyses related to BCRL treatment in Europe, Asia, Africa and South America are lacking. Worldwide, further scrutiny of the economic impact of DLT for BCRL in clinical settings is needed. CLINICAL TRIAL REGISTRATION NUMBER The review makes part of a double-blind, multi-center, randomized controlled trial (EFforT-BCRL trial), which is registered in clinicaltrials.gov (NCT02609724). CME reference S58689, EudraCT Number 2015-004822-33.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
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Costo de Enfermedad
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Linfedema del Cáncer de Mama
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Hospitalización
Tipo de estudio:
Clinical_trials
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Guideline
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Health_economic_evaluation
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Risk_factors_studies
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Systematic_reviews
Límite:
Adult
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Female
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Humans
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Middle aged
País/Región como asunto:
Asia
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Europa
Idioma:
En
Revista:
Support Care Cancer
Asunto de la revista:
NEOPLASIAS
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SERVICOS DE SAUDE
Año:
2020
Tipo del documento:
Article
País de afiliación:
Bélgica