Relationship Between Diabetes Mellitus and Cirrhosis Risk in Chronic Hepatitis B Patients in Wuhan, China.
Med Sci Monit
; 25: 8112-8119, 2019 Oct 29.
Article
en En
| MEDLINE
| ID: mdl-31661471
ABSTRACT
BACKGROUND The objective of our research was to assess the possible link between diabetes mellitus (DM) and liver cirrhosis in chronic hepatitis B (CHB) patients in Wuhan, China. MATERIAL AND METHODS Individuals with a diagnosis of both liver cirrhosis and chronic HBV infection (n=257), and CHB-only patients (n=514) were matched 1 2 by age and sex. Demographic, lifestyle, laboratory, and clinical characteristics were reviewed. Univariate and the multiple logistic regression analysis were conducted to investigate the association between DM and HBV-related liver cirrhosis. RESULTS The prevalence of DM was higher among CHB patients with liver cirrhosis than in those without liver cirrhosis (22.2% vs. 12.8%, P=0.001), yielding an adjusted odds ratio (AOR) of 2.317 and a 95% confidence interval (CI) of 1.528-3.513. Among them, 87.7% of liver cirrhosis patients were diagnosed with DM before liver cirrhosis diagnosis, yielding an AOR (95% CI) of 2.386 (1.533-3.714). In comparison to patients with a DM duration of 2-5 years, the AOR (95% CI) for those with a DM duration >5 years was 2.073 (0.701-6.132). In DM treatment, the AOR (95% CI) for those treated with insulin was 4.746 (1.329-16.949). CONCLUSIONS DM was associated with cirrhosis risk in CHB patients in Wuhan, China.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Hepatitis B Crónica
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Diabetes Mellitus
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Cirrosis Hepática
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Med Sci Monit
Asunto de la revista:
MEDICINA
Año:
2019
Tipo del documento:
Article