Cellular Senescence: Defining a Path Forward.
Cell
; 179(4): 813-827, 2019 10 31.
Article
en En
| MEDLINE
| ID: mdl-31675495
ABSTRACT
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http//Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Biomarcadores
/
Senescencia Celular
/
Enfermedades Genéticas Congénitas
Tipo de estudio:
Guideline
Límite:
Humans
Idioma:
En
Revista:
Cell
Año:
2019
Tipo del documento:
Article