Benzoyl peroxide use transiently decreases Cutibacterium acnes load on the shoulder.
J Shoulder Elbow Surg
; 29(4): 794-798, 2020 Apr.
Article
en En
| MEDLINE
| ID: mdl-31676186
ABSTRACT
BACKGROUND:
Cutibacterium acnes is the most common pathogen in shoulder prosthetic joint infections. Short-contact benzoyl peroxide (BPO) solutions effectively reduce C acnes loads on the shoulder preoperatively. It is unknown how long the effect of BPO lasts. We evaluated C acnes counts 1 week after BPO application. We hypothesized that BPO would decrease C acnes burden with a rebound after 1 week.METHODS:
Screening of 102 healthy volunteers with no history of shoulder surgery or C acnes infection was performed to establish bacterial counts. Thirty-four participants were selected based on an established threshold. Each was given BPO 5% for 3 consecutive days of application on either the left or right shoulder as indicated by a random number generator. Deep sebaceous gland cultures were obtained with a detergent scrub technique before BPO application, after 3 days of use, and 1 week after BPO treatment commenced.RESULTS:
The differences between the logarithmic reduction and the logarithmic rebound at the anterior, lateral, and posterior sites were statistically significant. Anteriorly, the average log reduction was -0.44 and the average log rebound was 0.69 (P = .003). Laterally, reduction was -0.64 and rebound was 0.74 (P = .003). Posteriorly, reduction was -0.63 and rebound was 0.78 (P = .008). At the axilla, reduction was -0.40 and rebound was 0.31 (P = .10). The differences in C acnes burden between pretreatment and 1-week counts at all sites were not statistically significant.CONCLUSION:
A significant decrease in C acnes burden occurred after BPO application but was not permanent. Significant rebound occurred just 1 week later.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Propionibacterium acnes
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Hombro
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Peróxido de Benzoílo
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Infecciones por Bacterias Grampositivas
Tipo de estudio:
Diagnostic_studies
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Observational_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Shoulder Elbow Surg
Asunto de la revista:
ORTOPEDIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos