In vivo generation of haematopoietic stem/progenitor cells from bone marrow-derived haemogenic endothelium.
Nat Cell Biol
; 21(11): 1334-1345, 2019 11.
Article
en En
| MEDLINE
| ID: mdl-31685991
ABSTRACT
It is well established that haematopoietic stem and progenitor cells (HSPCs) are generated from a transient subset of specialized endothelial cells termed haemogenic, present in the yolk sac, placenta and aorta, through an endothelial-to-haematopoietic transition (EHT). HSPC generation via EHT is thought to be restricted to the early stages of development. By using experimental embryology and genetic approaches in birds and mice, respectively, we document here the discovery of a bone marrow haemogenic endothelium in the late fetus/young adult. These cells are capable of de novo producing a cohort of HSPCs in situ that harbour a very specific molecular signature close to that of aortic endothelial cells undergoing EHT or their immediate progenies, i.e., recently emerged HSPCs. Taken together, our results reveal that HSPCs can be generated de novo past embryonic stages. Understanding the molecular events controlling this production will be critical for devising innovative therapies.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Células de la Médula Ósea
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Células Madre Hematopoyéticas
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Regulación del Desarrollo de la Expresión Génica
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Linaje de la Célula
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Hemangioblastos
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Nat Cell Biol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Francia