Photoinduced Decarboxylative Amino-Fluoroalkylation of Maleic Anhydride.
Chemistry
; 26(2): 419-422, 2020 Jan 07.
Article
en En
| MEDLINE
| ID: mdl-31705679
ABSTRACT
A photoinduced decarboxylative three-component coupling reaction involving amine, maleic anhydride, and fluorinated alkyl iodides has been developed, leading to synthetically valuable fluoroalkyl-containing acrylamides with a high E selectivity. A broad array of substrates including monoprotected amino acid are capable coupling partners. Preliminary mechanistic studies suggest a stepwise process. This reaction represents the first example of photoinduced decarboxylative difunctionalization of maleic anhydride.
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MEDLINE
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En
Revista:
Chemistry
Asunto de la revista:
QUIMICA
Año:
2020
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Article