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A Standard Numbering Scheme for Class C ß-Lactamases.
Mack, Andrew R; Barnes, Melissa D; Taracila, Magdalena A; Hujer, Andrea M; Hujer, Kristine M; Cabot, Gabriel; Feldgarden, Michael; Haft, Daniel H; Klimke, William; van den Akker, Focco; Vila, Alejandro J; Smania, Andrea; Haider, Shozeb; Papp-Wallace, Krisztina M; Bradford, Patricia A; Rossolini, Gian Maria; Docquier, Jean-Denis; Frère, Jean-Marie; Galleni, Moreno; Hanson, Nancy D; Oliver, Antonio; Plésiat, Patrick; Poirel, Laurent; Nordmann, Patrice; Palzkill, Timothy G; Jacoby, George A; Bush, Karen; Bonomo, Robert A.
Afiliación
  • Mack AR; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA.
  • Barnes MD; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.
  • Taracila MA; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Hujer AM; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.
  • Hujer KM; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Cabot G; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.
  • Feldgarden M; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Haft DH; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.
  • Klimke W; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • van den Akker F; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.
  • Vila AJ; Red Española de Investigación en Patología Infecciosa (REIPI), Instituto de Salud Carlos III, Madrid, Spain.
  • Smania A; Servicio de Microbiología, Hospital Universitario Son Espases, Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain.
  • Haider S; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
  • Papp-Wallace KM; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
  • Bradford PA; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
  • Rossolini GM; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
  • Docquier JD; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA.
  • Frère JM; Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Rosario, Argentina.
  • Galleni M; Plataforma Argentina de Biología Estructural y Metabolómica PLABEM, Buenos Aires, Argentina.
  • Hanson ND; Área Biofísica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.
  • Oliver A; Centro de Investigaciones en Química Biológica de Córodoba (CIQUIBIC), CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina.
  • Plésiat P; Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
  • Poirel L; UCL School of Pharmacy, University College London, London, United Kingdom.
  • Nordmann P; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Palzkill TG; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
  • Jacoby GA; Department of Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, USA.
  • Bush K; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.
  • Bonomo RA; Antimicrobial Development Specialists, LLC, Nyack, New York, USA.
Antimicrob Agents Chemother ; 64(3)2020 02 21.
Article en En | MEDLINE | ID: mdl-31712217
ABSTRACT
Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) ß-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Beta-Lactamasas / Resistencia betalactámica / Bacterias Gramnegativas / Bacterias Grampositivas / Mutación / Terminología como Asunto Idioma: En Revista: Antimicrob Agents Chemother Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Beta-Lactamasas / Resistencia betalactámica / Bacterias Gramnegativas / Bacterias Grampositivas / Mutación / Terminología como Asunto Idioma: En Revista: Antimicrob Agents Chemother Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos