A Standard Numbering Scheme for Class C ß-Lactamases.
Antimicrob Agents Chemother
; 64(3)2020 02 21.
Article
en En
| MEDLINE
| ID: mdl-31712217
ABSTRACT
Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) ß-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Beta-Lactamasas
/
Resistencia betalactámica
/
Bacterias Gramnegativas
/
Bacterias Grampositivas
/
Mutación
/
Terminología como Asunto
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos