C-type lectin-like receptor 2 and zonulin are associated with mild cognitive impairment and Alzheimer's disease.
Acta Neurol Scand
; 141(3): 250-255, 2020 Mar.
Article
en En
| MEDLINE
| ID: mdl-31715011
ABSTRACT
OBJECTIVE:
Increased permeability and changes in gut microbiota contributed to the pathogenesis of Alzheimer's disease (AD). Zonulin is a key modulator that regulates intestinal barrier function. Peripheral platelet alterations have been involved in AD pathology. C-type lectin-like receptor 2 (CLEC-2) is a receptor on the platelet surface for activation. The purpose of this study was to determine zonulin and CLEC-2 levels in mild cognitive impairment (MCI) and AD, and investigate the relationship between zonulin and CLEC-2.METHODS:
In this study, CLEC-2 and zonulin levels were measured using ELISA assay in 110 AD patients, 110 MCI patients, and 110 non-demented control subjects.RESULTS:
Increased CLEC-2 and zonulin levels were observed in MCI and AD patients. Furthermore, AD patients had higher CLEC-2 and zonulin levels compared with MCI patients. In addition, CLEC-2 levels were positively correlated with zonulin levels, after adjusting confounding factors (r = .592, P < .001). Multivariate analysis revealed that increased CLEC-2 and zonulin levels were significantly associated with reduced Mini-Mental State Examination (MMSE) score.CONCLUSIONS:
C-type lectin-like receptor 2 is correlated with zonulin after adjusting confounding covariates. Moreover, increased CLEC-2 and zonulin are the significant factors for reduced MMSE score in MCI and AD. Further studies are needed.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Precursores de Proteínas
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Lectinas Tipo C
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Enfermedad de Alzheimer
/
Disfunción Cognitiva
Tipo de estudio:
Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Acta Neurol Scand
Año:
2020
Tipo del documento:
Article
País de afiliación:
China