Platelet Acetyl-CoA Carboxylase Phosphorylation: A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients.
JACC Basic Transl Sci
; 4(5): 596-610, 2019 Sep.
Article
en En
| MEDLINE
| ID: mdl-31768476
ABSTRACT
Adenosine monophosphate-activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) signaling is activated in platelets by atherogenic lipids, particularly by oxidized low-density lipoproteins, through a CD36-dependent pathway. More interestingly, increased platelet AMPK-induced ACC phosphorylation is associated with the severity of coronary artery calcification as well as acute coronary events in coronary artery disease patients. Therefore, AMPK-induced ACC phosphorylation is a potential marker for risk stratification in suspected coronary artery disease patients. The inhibition of ACC resulting from its phosphorylation impacts platelet lipid content by down-regulating triglycerides, which in turn may affect platelet function.
ACC, acetyl-CoA carboxylase; AMPK; AMPK, adenosine monophosphateactivated protein kinase; AU, arbitrary units; AoC, extra-coronary calcification score; CAC, coronary artery calcification; CAD, coronary artery disease; S-CAD, stable coronary artery disease; TG, triglyceride; acetyl-CoA carboxylase; coronary artery disease; lipidomics; oxLDL, oxidized low-density lipoprotein; phosphoACC, acetyl-CoA carboxylase phosphorylation on serine 79; platelet
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MEDLINE
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
JACC Basic Transl Sci
Año:
2019
Tipo del documento:
Article
País de afiliación:
Bélgica