NTMS mapping of non-primary motor areas in brain tumour patients and healthy volunteers.
Acta Neurochir (Wien)
; 162(2): 407-416, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-31768755
ABSTRACT
OBJECTIVE:
Navigated transcranial magnetic stimulation (nTMS) has been increasingly used for presurgical cortical mapping of the primary motor cortex (M1) but remains controversial for the evaluation of non-primary motor areas (NPMA). This study investigates clinical and neurophysiological parameters in brain tumour patients and healthy volunteers to decide whether single-pulse biphasic nTMS allows to reliably elicite MEP outside from M1 or not. MATERIALS ANDMETHODS:
Twelve brain tumour patients and six healthy volunteers underwent M1 nTMS mapping. NPMA nTMS mapping followed using 120% and 150% M1 resting motor threshold (RMT) stimulation intensity. Spearman's correlation analysis tested the association of clinical and neurophysiological parameters between M1 and NPMA mapping.RESULTS:
A total of 88.81% of nTMS stimulations in NPMA in patients/83.87% in healthy volunteers in patients/83.87% in healthy volunteers did not result in MEPs ≥ 50 µV. Positive nTMS mapping in NPMA correlated with higher stimulation intensity and larger M1 areas in patients (120% M1 RMT SI p = 0.005/150% M1 RMT SI p = 0.198).CONCLUSION:
Our findings indicate that in case of positive nTMS mapping in NPMA, MEPs originate mostly from M1. For future studies, MEP parameters and TMS coil rotation should be studied closely to assess the risk for postoperative motor deterioration.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Mapeo Encefálico
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Neoplasias Encefálicas
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Neuronavegación
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Estimulación Magnética Transcraneal
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Corteza Motora
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Acta Neurochir (Wien)
Año:
2020
Tipo del documento:
Article
País de afiliación:
Alemania