The frequency of CpG and non-CpG methylation of Notch3 gene promoter determines its expression levels in breast cancer cells.

Xiao, Wenjun; Liu, Xiong; Niu, Xia; Li, Chun; Guo, Yuxian; Tan, Junyu; Xiong, Wei; Fan, Liping; Li, Yaochen

Xiao, Wenjun; Liu, Xiong; Niu, Xia; Li, Chun; Guo, Yuxian; Tan, Junyu; Xiong, Wei; Fan, Liping; Li, Yaochen.

Afiliación

Xiao W; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China; Present Address: Health Science Center of Shenzhen University Medical College, Shenzhen, 518055, China.
Liu X; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China.
Niu X; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China.
Li C; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China.
Guo Y; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China.
Tan J; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China.
Xiong W; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China.
Fan L; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China.
Li Y; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China. Electronic address: yaochenli-2004@163.com.

Exp Cell Res ; 386(2): 111743, 2020 01 15.

Article en En | MEDLINE | ID: mdl-31770532

Asunto(s)

Epigénesis Genética; Regulación Neoplásica de la Expresión Génica; Regiones Promotoras Genéticas; Receptor Notch3/genética; Antimetabolitos Antineoplásicos/farmacología; Secuencia de Bases; Línea Celular Tumoral; Islas de CpG; ADN (Citosina-5-)-Metiltransferasa 1/genética; ADN (Citosina-5-)-Metiltransferasa 1/metabolismo; ADN (Citosina-5-)-Metiltransferasas/genética; ADN (Citosina-5-)-Metiltransferasas/metabolismo; Metilación de ADN/efectos de los fármacos; Decitabina/farmacología; Proteína Potenciadora del Homólogo Zeste 2/genética; Proteína Potenciadora del Homólogo Zeste 2/metabolismo; Femenino; Genes Reporteros; Humanos; Luciferasas/genética; Luciferasas/metabolismo; Células MCF-7; Proteína 2 de Unión a Metil-CpG/genética; Proteína 2 de Unión a Metil-CpG/metabolismo; Receptor Notch3/deficiencia; Transducción de Señal; Neoplasias de la Mama Triple Negativas/genética; Neoplasias de la Mama Triple Negativas/metabolismo; Neoplasias de la Mama Triple Negativas/patología; ADN Metiltransferasa 3B

Palabras clave

Breast cancer cells; DNMTs; EZH2; Mecp2; Non-CpG (CpHs) methylation; Notch3

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Regiones Promotoras Genéticas / Epigénesis Genética / Receptor Notch3 Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Exp Cell Res Año: 2020 Tipo del documento: Article País de afiliación: China

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