MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract.

Aryal, Sandeep; Anand, Deepti; Hernandez, Francisco G; Weatherbee, Bailey A T; Huang, Hongzhan; Reddy, Ashok P; Wilmarth, Phillip A; David, Larry L; Lachke, Salil A

Aryal, Sandeep; Anand, Deepti; Hernandez, Francisco G; Weatherbee, Bailey A T; Huang, Hongzhan; Reddy, Ashok P; Wilmarth, Phillip A; David, Larry L; Lachke, Salil A.

Afiliación

Aryal S; Department of Biological Sciences, University of Delaware, 105 The Green, Delaware Avenue, 236 Wolf Hall, Newark, DE, USA.
Anand D; Department of Biological Sciences, University of Delaware, 105 The Green, Delaware Avenue, 236 Wolf Hall, Newark, DE, USA.
Hernandez FG; Department of Biological Sciences, University of Delaware, 105 The Green, Delaware Avenue, 236 Wolf Hall, Newark, DE, USA.
Weatherbee BAT; Department of Biological Sciences, University of Delaware, 105 The Green, Delaware Avenue, 236 Wolf Hall, Newark, DE, USA.
Huang H; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, 19716, USA.
Reddy AP; Proteomics Shared Resource, Oregon Health and Science University, Portland, OR, 97239, USA.
Wilmarth PA; Proteomics Shared Resource, Oregon Health and Science University, Portland, OR, 97239, USA.
David LL; Proteomics Shared Resource, Oregon Health and Science University, Portland, OR, 97239, USA.
Lachke SA; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR, 97239, USA.

Hum Genet ; 139(2): 151-184, 2020 Feb.

Article en En | MEDLINE | ID: mdl-31797049

Asunto(s)

Biomarcadores/metabolismo; Catarata/metabolismo; Simulación por Computador; Proteínas del Ojo/metabolismo; Cristalino/metabolismo; Proteoma/metabolismo; Espectrometría de Masas en Tándem/métodos; Animales; Catarata/genética; Catarata/patología; Biología Computacional; Proteínas del Ojo/genética; Perfilación de la Expresión Génica; Humanos; Cristalino/embriología; Ratones; Ratones Endogámicos C57BL; Proteoma/análisis; Transcriptoma

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Catarata / Simulación por Computador / Biomarcadores / Proteoma / Proteínas del Ojo / Espectrometría de Masas en Tándem / Cristalino Límite: Animals / Humans Idioma: En Revista: Hum Genet Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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