Whole Genome Expression Analyses of miRNAs and mRNAs Suggest the Involvement of miR-320a and miR-155-3p and their Targeted Genes in Lithium Response in Bipolar Disorder.

Pisanu, Claudia; Merkouri Papadima, Eleni; Melis, Carla; Congiu, Donatella; Loizedda, Annalisa; Orrù, Nicola; Calza, Stefano; Orrù, Sandro; Carcassi, Carlo; Severino, Giovanni; Ardau, Raffaella; Chillotti, Caterina; Del Zompo, Maria; Squassina, Alessio

Pisanu, Claudia; Merkouri Papadima, Eleni; Melis, Carla; Congiu, Donatella; Loizedda, Annalisa; Orrù, Nicola; Calza, Stefano; Orrù, Sandro; Carcassi, Carlo; Severino, Giovanni; Ardau, Raffaella; Chillotti, Caterina; Del Zompo, Maria; Squassina, Alessio.

Afiliación

Pisanu C; Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.
Merkouri Papadima E; Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.
Melis C; Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.
Congiu D; Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.
Loizedda A; Consiglio Nazionale delle Ricerche (C.n.R.), Istituto di Ricerca Genetica e Biomedica (I.R.G.B.), Monserrato, 09042 Cagliari, Italy.
Orrù N; Medical Genetics, R. Binaghi Hospital, ASSL Cagliari, ATS Sardegna, 09021 Cagliari, Italy.
Calza S; Unit of Biostatistics and Bioinformatics, Department of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy.
Orrù S; Big & Open Data Innovation Laboratory, University of Brescia, 25121 Brescia, Italy.
Carcassi C; Medical Genetics, R. Binaghi Hospital, ASSL Cagliari, ATS Sardegna, 09021 Cagliari, Italy.
Severino G; Medical Genetics, Department of Medical Sciences and Public Health, University of Cagliari, 09042 Cagliari, Italy.
Ardau R; Medical Genetics, R. Binaghi Hospital, ASSL Cagliari, ATS Sardegna, 09021 Cagliari, Italy.
Chillotti C; Medical Genetics, Department of Medical Sciences and Public Health, University of Cagliari, 09042 Cagliari, Italy.
Del Zompo M; Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.
Squassina A; Unit of Clinical Pharmacology of the University Hospital of Cagliari, 09042 Cagliari, Italy.

Int J Mol Sci ; 20(23)2019 Nov 30.

Article en En | MEDLINE | ID: mdl-31801218

Asunto(s)

Trastorno Bipolar/tratamiento farmacológico; Litio/uso terapéutico; MicroARNs/genética; Psicotrópicos/uso terapéutico; ARN Mensajero/genética; Adulto; Trastorno Bipolar/genética; Trastorno Bipolar/metabolismo; Trastorno Bipolar/fisiopatología; Calpaína/genética; Calpaína/metabolismo; Línea Celular; Femenino; Perfilación de la Expresión Génica; Regulación de la Expresión Génica; Genoma Humano; Humanos; Linfocitos/efectos de los fármacos; Linfocitos/metabolismo; Linfocitos/patología; Masculino; MicroARNs/clasificación; MicroARNs/metabolismo; Persona de Mediana Edad; Análisis de Secuencia por Matrices de Oligonucleótidos; Cultivo Primario de Células; Proteínas RGS/genética; Proteínas RGS/metabolismo; ARN Mensajero/clasificación; ARN Mensajero/metabolismo; Estudios Retrospectivos; Factor de Transcripción Sp4/genética; Factor de Transcripción Sp4/metabolismo; Resultado del Tratamiento

Palabras clave

epigenetics; miRNA; microRNA; mood disorders; mood stabilizers; next generation sequencing; pharmacogenetics

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Psicotrópicos / Trastorno Bipolar / ARN Mensajero / MicroARNs / Litio Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Año: 2019 Tipo del documento: Article País de afiliación: Italia

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