Inhaled nitric oxide use in neonates: Balancing what is evidence-based and what is physiologically sound.

Sherlock, Laurie G; Wright, Clyde J; Kinsella, John P; Delaney, Cassidy

Sherlock, Laurie G; Wright, Clyde J; Kinsella, John P; Delaney, Cassidy.

Afiliación

Sherlock LG; Section of Neonatology, Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, 80045, USA.
Wright CJ; Section of Neonatology, Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, 80045, USA.
Kinsella JP; Section of Neonatology, Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, 80045, USA.
Delaney C; Section of Neonatology, Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, 80045, USA. Electronic address: Cassidy.delaney@childrenscolorado.org.

Nitric Oxide ; 95: 12-16, 2020 02 01.

Article en En | MEDLINE | ID: mdl-31866361

ABSTRACT

ABSTRACT

Inhaled nitric oxide is a powerful therapeutic used in neonatology. Its use is evidenced-based for term and near-term infants with persistent pulmonary hypertension; however, it is frequently used off-label both in term and preterm babies. This article reviews the off-label uses of iNO in infants. Rationale is discussed for a selective application of iNO based on physiologically guided principles, and new research avenues are considered.

Asunto(s)

Medicina Basada en la Evidencia; Hipertensión Pulmonar/tratamiento farmacológico; Óxido Nítrico/administración & dosificación; Óxido Nítrico/uso terapéutico; Administración por Inhalación; Humanos; Recién Nacido

Palabras clave

Bronchopulmonary dysplasia; Neonate; Nitric oxide; Persistent pulmonary hypertension of the newborn; Pulmonary arterial hypertension; Respiratory failure

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Medicina Basada en la Evidencia / Hipertensión Pulmonar / Óxido Nítrico Límite: Humans / Newborn Idioma: En Revista: Nitric Oxide Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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