Elevated system exposures of baicalin after combinatory oral administration of rhein and baicalin: Mainly related to breast cancer resistance protein (ABCG2), not UDP-glucuronosyltransferases.

Zhang, Yaqing; Zhang, Mei; Hu, Guangnan; Zhang, Zunjian; Song, Rui

Zhang, Yaqing; Zhang, Mei; Hu, Guangnan; Zhang, Zunjian; Song, Rui.

Afiliación

Zhang Y; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, 24 Tongjia Lane, Nanjing, 210009, China; State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, 210009, China; Analysis Center, Hubei Bio-Pharmaceutical Industrial Technologica
Zhang M; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, 24 Tongjia Lane, Nanjing, 210009, China; State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: zhang-m-x@foxmail.com.
Hu G; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, 24 Tongjia Lane, Nanjing, 210009, China; State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: tsimhappy@163.com.
Zhang Z; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, 24 Tongjia Lane, Nanjing, 210009, China; State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: zunjianzhangcpu@hotmail.com.
Song R; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, 24 Tongjia Lane, Nanjing, 210009, China; State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: songrui_cpu@163.com.

J Ethnopharmacol ; 250: 112528, 2020 Mar 25.

Article en En | MEDLINE | ID: mdl-31884038

Asunto(s)

Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 2/metabolismo; Antraquinonas/farmacología; Flavonoides/farmacocinética; Glucuronosiltransferasa/metabolismo; Administración Oral; Animales; Antraquinonas/administración & dosificación; Área Bajo la Curva; Disponibilidad Biológica; Transporte Biológico; Perros; Interacciones Farmacológicas; Enterocitos/metabolismo; Flavonoides/administración & dosificación; Hepatocitos/metabolismo; Humanos; Absorción Intestinal; Células de Riñón Canino Madin Darby; Masculino; Microsomas Hepáticos/metabolismo; Ratas; Ratas Sprague-Dawley; Rheum/química

Palabras clave

Baicalin; Bioavailability; Breast cancer resistance protein; Rhein; Uridine diphosphate-glucuronosyltransferases

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Flavonoides / Antraquinonas / Glucuronosiltransferasa / Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 2 Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Ethnopharmacol Año: 2020 Tipo del documento: Article

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